top of page
About MiRAD
®
Home / MiRAD®
Scaling Radiological Response Through Molecular Innovation
About MiRAD
®
MiRAD® is a patented high-throughput biological dose reconstruction for triage when integrated into unidirectional molecular workflow laboratories and established international triage protocols. Its validated workflow enables rapid, quantitative individual dose assessment across a clinically relevant range of 0–10 Gy, supporting informed clinical triage and medical management decisions. MiRAD® is designed to operate in alignment with WHO BioDoseNet frameworks and FDA medical countermeasure guidelines, ensuring regulatory consistency and interoperability during large-scale radiological response operations.
Molecular Dosimetry
The MiRAD Platform
MiRAD’s biodosimetry assay leverages an engineered, high-throughput microRNA (miRNA) biomarker platform specifically designed to quantitatively assess radiation exposure. With a rapid processing time of approximately five hours, the assay provides timely, operationally relevant decision support during the critical early phase of large-scale radiological incidents. By combining precision biomarker detection with high-throughput capabilities, MiRAD enables emergency response teams to quickly identify affected individuals, prioritize care, and make informed triage decisions when every hour counts.
®
Radiological Defense: From Stockpiles to Capability
-
Standardized biodosimetry assay for alliance-wide triage, aligned with WHO BioDoseNet frameworks.
-
Integrates into existing high-throughput molecular labs across member states – no new core hardware required.
-
Structured as Vendor-Managed Inventory (VMI) with surge production guarantees for declared crises.
Performance & Technical Advantage
The MiRAD® platform combines high-throughput operational capacity with advanced molecular precision, enabling rapid, large-scale radiation dose assessment through a minimally invasive and scientifically validated workflow.
High-Throughput Processing
Validated capacity of >10,000 samples per 24 hours using standardized unidirectional molecular workflows in high-density qPCR laboratories with continuous staffing.
Minimally Invasive Sampling
Requires only two drops of blood, enabling rapid collection and efficient large-scale screening with minimal burden on patients.
Accurate Dose Estimation
Delivers absorbed dose measurement with ±1.0 Gy accuracy and a broad analytical range up to 7 days post-exposure, supporting confident clinical decision-making.
Scientific & Regulatory Foundation
Founded through scientific development led by Dr. Jacob Naduparambil in partnership with The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) at The Ohio State University Wexner Medical Center, the platform innovation genesis is co-funded by NIH/NIAID, DOD-CDMRP, NASA, and Ohio’s TVSF pathways.
MiRAD’s unique dual miRNA design for biological normalization aligns with international triage protocols. By adhering to international emergency preparedness guidelines tailored to WHO BioDoseNet frameworks, MiRAD aims to ensure that high-volume biodosimetry is both metrologically traceable and operationally scalable for global health security.
Laboratory Overview
About the Lab
MiRAD® can be implemented in any high-complexity molecular diagnostic laboratory, providing reliable results within 5–8 hours. Because the assay does not require specialized instruments, laboratories can be rapidly scaled using commercially available equipment to accommodate high-volume sample processing needs. This flexibility enables organizations to quickly expand operational capacity in response to large-scale radiological incidents, ensuring that critical triage and biodosimetry decisions can be made promptly.
MiRAD® protocols are designed for use across:
-
Standard high-throughput, unidirectional molecular workflow labs.
-
Lab networks already configured for large-scale qPCR testing.
-
24/7 staffed facilities that can be rapidly brought into an alliance-wide operational plan.
Rapid Triage
MiRAD – Molecular Innovation in Radiology
MiRAD® provides a validated, end-to-end solution for critical triage decision-making during radiological emergencies. Our fully scalable program delivers access to scientifically validated triage assays and flexible instrument deployment configurations, tailored to each customer’s resources, operational constraints, and mission-specific threat models. By combining advanced triage methodologies with customizable deployment strategies, MiRAD® enables rapid, informed decision-making, optimizes resource allocation, and enhances preparedness for radiological incidents across a wide range of operational environments.
®
bottom of page